I think, if I recall, this would be the third or fourth time I've seen Pontypool. And I'm still not sure how I really feel.
On one hand, I wish they had delved into the logic behind the infection/disease a hell of a lot more. On the other hand, the characters present didn't know, nor had any idea how to really find out, and were more concerned about their own survival as opposed to the hows and the whys of this disease. The doctor, who's personality was deeply amusing, was of little help, and seemed moderately unhinged himself, but still did what he could to help out the main characters.
The chaos in this film is very heavy, and coupled with the fact that we really don't have an answer as to how this infection came about by the end of the movie, really makes it a hard one to judge. The idea of hearing second hand the horrors going on outside was pretty cool, which reminded me of another film, being Dead Air (2009, starring Bill Moseley).
Stephen McHattie was a decent actor in his own right, but there are the occasional awkward scenes/lines. And the post-credit scene, well, I still have exactly zero idea what to make of that, despite the various theories I've read online. Pontypool is a mostly-claustrophobic film, some high-level suspense, and contains a somewhat confusing premise. Even after three or four viewings, I'm still not sure what to make of it. It definitely makes you think, though. 6.5/10 (rounded down to 6/10 to fit site's format).